DYR_THEMA_2_169

Dihydrofolate reductase [Dihydrofolate reductase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DYR_THEMA):D: DHFR (7:9,28:30,32,33,51,52,54,56,59,101)
R: Substrate binding (7,8)
R: Substrate binding (28:30)
7:9,28:30,32,33,51,52,54,56,59,101
Cofactors (cF):ndp

Full PDB list

1cz3,1d1g

Contact map

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ligand
A1 cF
V
7
L
8
A
9
D
2
8
R
2
9
K
3
0
F
3
2
R
3
3
E
5
1
I
5
2
R
5
4
L
5
6
R
5
9
I
1
0
1
[1]1d1g.a mtx 33 . . . . . . . . . . . . . . ndp
[1]1cz3.a none . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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