DYR_PNECA_1_206

Dihydrofolate reductase [Dihydrofolate reductase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DYR_PNECA):D: DHFR (10:12,24,25,27,32,33,36,37,61,64:66,69,72,73,75,123,129,144)
R: Substrate binding (32,33,36,37)
0
0,10:12,24,25,27,32,33,36,37,61,64:66,69,72,73,75,123,129,144
Cofactors (cF):nap/ndp

Full PDB list

1cd2,1daj,1dyr,1e26,1klk,1ly3,1ly4,1s3y,1vj3,2cd2,2fzh,2fzi,3cd2,3nz6,3nz9,3nza,3nzb,3nzc,3td8,4cd2,4g8z,4ixe,4ixf,4ixg,4qjz (redundant pocketome entry)

Contact map

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ligand
A1 cF
.
0
I
1
0
V
1
1
A
1
2
S
2
4
L
2
5
W
2
7
E
3
2
I
3
3
F
3
6
K
3
7
T
6
1
S
6
4
I
6
5
P
6
6
F
6
9
L
7
2
K
7
3
R
7
5
I
1
2
3
Y
1
2
9
T
1
4
4
[1]3nz6.x d2j 31 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]3nzb.x d2n,d2n 66 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]3nzc.x d2o 31 - . . . . . . . . . . . . . . . . . . . . .
[1]3td8.a d2r 30 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]1e26.a gpb 31 - . . . . . . . . . . . . . . . . . . . . . nap
[1]1klk.a pmd 28 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]1vj3.a tab 33 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]1ly3.a cog 25 - . . . . . . . . . . . . . . . . . . . . . nap
[1]1ly4.a coq 25 - . . . . . . . . . . . . . . . . . . . . . nap
[1]3nz9.x d2k 31 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]2fzi.a dh3 27 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]4qjz.d 33m 24 * . . . . . . . . . . . . . . . . . . . . .
[1]4ixe.d ixe 23 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]4ixf.x ixf 23 - . . . . . . . . . . . . . . N . . . . . . ndp
[1]1daj.a mot 32 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]1s3y.a tqt 22 - . . . . . . . . . . . . . . . . . . . . . nap
[1]4ixg.x ixg 20 - . . . . . . . . . S . . . . N . . . . . . ndp
[1]3cd2.a mtx 33 - . . . . . . . . . . . . . . . . . . . . . nap
[1]2fzh.a dh1 25 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]1dyr.a top 21 - . . . . . . . . . . . . . . . . . . . . . ndp
[1]2cd2.a fol 32 - . . . . . . . . . . . . . . . . . . . . . nap
[1]4g8z.x top 21 - . . . . . . . . . S . . . . N . . . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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