DYR_MYCTU_4_161

Dihydrofolate reductase [Dihydrofolate reductase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DYR_MYCTU):D: DHFR (7:9,22,25,29:31,33,34,44,48,51:53,55,56,59,62,96,97,102)
R: Substrate binding (7:9)
7:9,22,25,29:31,33,34,44,48,51:53,55,56,59,62,96,97,102
Cofactors (cF):1dg/atr/ndp

Full PDB list

1df7,1dg5,1dg7,1dg8,2cig,4kl9,4klx,4km0,4km2,4kne,4m2x,5ja3 (redundant pocketome entry)

Contact map

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ligand
A1 cF
I
7
W
8
A
9
I
2
2
R
2
5
D
2
9
Q
3
0
A
3
1
F
3
3
R
3
4
M
4
4
T
4
8
S
5
1
L
5
2
P
5
3
K
5
5
V
5
6
L
5
9
R
6
2
I
9
6
G
9
7
Y
1
0
2
[1]5ja3.b u06 30 . . . . . . . . . . . . . . . . . . . . . . ndp
[1]1dg7.a wrb 22 . . . . . . . . . . . . . . . . . . . . . . ndp
[1]4m2x.e tmq 27 . . . . . . . . . . . . . . . . . . . . . . ndp
[1]1df7.a mtx 33 . . . . . . . . . . . . . . . . . . . . . . ndp
[1]4km2.a top 21 . . . . . . . . . . . . . . . . . . . . . . atr
[1]4kne.a 1cy 17 . . . . . . . . . . . . . . . . . . . . . . atr
[1]4km0.a cp6 17 . . . . . . . . . . . . . . . . . . . . . . atr
[1]2cig.a none . . . . . . . . . . . V . . . . . . . . . . 1dg
[1]4kl9.a none . . . . . . . . . . . . . . . . . . . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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