DYR_MOUSE_2_187

Dihydrofolate reductase [Dihydrofolate reductase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DYR_MOUSE):D: DHFR (8:10,21:23,31,32,35,36,57,60:62,65,68,69,71,116,122,137)
R: Substrate binding (31,32,35,36)
8:10,21:23,31,32,35,36,57,60:62,65,68,69,71,116,122,137
Cofactors (cF):ndp

Full PDB list

1u70,2fzj,3d80,3d84,3k45,3k47

Contact map

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ligand
A1 cF
I
8
V
9
A
1
0
G
2
1
D
2
2
L
2
3
E
3
1
F
3
2
F
3
5
Q
3
6
T
5
7
S
6
0
I
6
1
P
6
2
N
6
5
L
6
8
K
6
9
R
7
1
V
1
1
6
Y
1
2
2
T
1
3
7
[1]3d80.a q22 29 . . . . . . . . . . . . . . . . . . . . . ndp
[1]2fzj.a dh3 27 . . . . . . . . . . . . . . . . . . . . . ndp
[1]1u70.a mtx 33 . . . . . R . . . . . . . . . . . . . . . ndp
[1]3k45.a 51p 21 . . . . . . . . . . . . . . . . . . . . . ndp
[1]3d84.x none . . . . . . . . . . . . . . . . . . . . . ndp
[1]3k47.a d09 22 . . . . . . . . . . . . . . . . . . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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