DYR_CANAX_1_192

Dihydrofolate reductase [Dihydrofolate reductase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DYR_CANAX):D: DHFR (9:11,25,32,33,36,37,58,61:63,66,69,112,118)
R: Substrate binding (32,33,36,37)
9:11,25,32,33,36,37,58,61:63,66,69,112,118
Cofactors (cF):ndp

Full PDB list

1ai9,1aoe,1ia1,1ia2,1ia3,1ia4,1m78,1m79,1m7a,3qlr,3qls,3qlw,4h95,4h96,4h97,4hoe,4hof (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1 cF
I
9
V
1
0
A
1
1
M
2
5
E
3
2
I
3
3
F
3
6
K
3
7
T
5
8
S
6
1
I
6
2
P
6
3
F
6
6
L
6
9
I
1
1
2
Y
1
1
8
[1]4h96.b 14q 30 . . . . . . . . . . . . . . . . ndp
[1]4hoe.b 18g 29 . . . . . . . . . . . . . . . . ndp
[1]4hof.b 18h 27 . . . . . . . . . . . . . . . . ndp
[1]4h97.b 53s 28 . . . . . . . . . . . . . . . . ndp
[1]3qlr.a qlr 26 . . . . . . . . . . . . . . . . ndp
[1]1ia3.b none . . . . . . . . . . . . . . . . ndp
[1]3qls.a 55v 26 . . . . . . . . . . . . . . . . ndp
[1]1m7a.b mqu 22 . . . . . . . . . . . . . . . . ndp
[1]1m79.b mq1 21 . . . . . . . . . . . . . . . . ndp
[1]1aoe.a gw3 20 . . . . . . . . . . . . . . . . ndp
[1]1ia2.b tq4 20 . . . . . . . . . . . . . . . . ndp
[1]4h95.a 06u 28 . . . . . . . . . . . . . . . . ndp
[1]1ia1.b tq3 19 . . . . . . . . . . . . . . . . ndp
[1]3qlw.a n22 23 . . . . . . . . . . . . . . . . ndp
[1]1m78.b clz 14 . . . . . . . . . . . . . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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