DYRK2_HUMAN_145_550

Dual specificity tyrosine-phosphorylation-regulated kinase 2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DYRK2_HUMAN):D: Protein kinase (228:230,233,236,249,251,285,301:307,352,355,367,368)228:230,233,236,249,251,285,301:307,352,355,367,368

Full PDB list

3k2l,3kvw,4azf,5lxc,5lxd

Contact map

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ligand
A1
I
2
2
8
G
2
2
9
K
2
3
0
F
2
3
3
V
2
3
6
A
2
4
9
K
2
5
1
I
2
8
5
F
3
0
1
E
3
0
2
L
3
0
3
L
3
0
4
S
3
0
5
M
3
0
6
N
3
0
7
E
3
5
2
L
3
5
5
I
3
6
7
D
3
6
8
[1]5lxd.a 7a7 27 . . . . . . . . . . . . . . . . . . .
[1]5lxc.a 7aa 26 . . . . . . . . . . . . . . . . . . .
[1]3kvw.a irb 25 . . . . . . . . . . . . . . . . . . .
[1]4azf.a 3ra 23 . . . . . . . . . . . . . . . . . . .
[1]3k2l.a none . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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