DYR1A_HUMAN_124_488

Dual specificity tyrosine-phosphorylation-regulated kinase 1A [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DYR1A_HUMAN):D: Protein kinase (165:168,170:173,186,188,203,222,238:244,291,292,294,306,307)165:168,170:173,186,188,203,222,238:244,291,292,294,306,307

Full PDB list

2vx3,2wo6,3anq,3anr,4aze,4mq1,4mq2,4nct,4ylj,4ylk,4yll,4yu2,5a3x,5a4e,5a4l,5a4q,5a4t,5a54,5aik (redundant pocketome entry)

Contact map

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ligand
A1
I
1
6
5
G
1
6
6
K
1
6
7
G
1
6
8
F
1
7
0
G
1
7
1
Q
1
7
2
V
1
7
3
A
1
8
6
K
1
8
8
E
2
0
3
V
2
2
2
F
2
3
8
E
2
3
9
M
2
4
0
L
2
4
1
S
2
4
2
Y
2
4
3
N
2
4
4
E
2
9
1
N
2
9
2
L
2
9
4
V
3
0
6
D
3
0
7
[1]4mq2.c 2c4 27 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5aik.a awr 24 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4mq1.a 2c3 37 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ylk.a 4e2 22 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4yll.a 4e3 22 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ylj.a 4e1 21 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4yu2.a 4h5 19 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4aze.a 3ra 23 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5a54.a 5pw 16 . . . . . . . . . . . . . . . . . . . . . . . .
[1]3anq.a ehb 16 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5a4e.c 7qq 15 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5a4t.c ajg 15 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5a3x.a qiv 14 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5a4q.a y3l 14 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5a4l.d zc3 14 . . . . . . . . . . . . . . . . . . . . . . . .
[1]3anr.a hrm 16 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4nct.a 2k2 43 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2wo6.a d15 32 . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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