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DUS22_HUMAN_1_163

Dual specificity protein phosphatase 22 [Protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily]

Composition of the binding site

Protein chains homodimer [domain annotation]
A1 (DUS22_HUMAN):D: Tyrosine-protein phosphatase (88:94)
57
57, 88:94
A2 (DUS22_HUMAN):7:107:10

Full PDB list

1wrm, 4woh

Pocket contact map

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PDB.ch
   
ligand
A1 A2
D
5
7
C
8
8
L
8
9
A
9
0
G
9
1
V
9
2
S
9
3
R
9
4
K
7
I
8
L
9
P
1
0
[1]1wrm.a none . . . . . . . . . . . .
[1]4woh.a 4np14 . S . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 A2
D
5
7
C
8
8
L
8
9
A
9
0
G
9
1
V
9
2
S
9
3
R
9
4
K
7
I
8
L
9
P
1
0
[1]1wrm.a . . . . . . . . . . . .
[1]4woh.a . S . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1wrm.a is apo
4woh.a:4np
[1] 1wrm.a
-
0.3
[1] 4woh.a -
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1wrm.a
4woh.a
[1] 1wrm.a
0
.02
[1] 4woh.a .02
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1wrm.a
4woh.a
[1] 1wrm.a
0
0.5
[1] 4woh.a 0.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1wrm.a
4woh.a
[1] 1wrm.a
0
0.6
[1] 4woh.a 0.6
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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