DRTS_TRYCR_1_521

Bifunctional dihydrofolate reductase-thymidylate synthase

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DRTS_TRYCR):D: DHFR (26:28,39,41,43:45,48,49,52,53,80,83:85,88,91,94,154,160,178)
R: Thymidylate synthase (257,403,404,423,424,426,430,434,464,466)
26:28,39,41,43:45,48,49,52,53,80,83:85,88,91,94,154,160,178,257,403,404,423,424,426,430,434,464,466
Cofactors (cF):nap/nap-du/ndp/ndp.ump

Full PDB list

2h2q,3cl9,3clb,3hbb,3inv,3irm,3irn,3iro,3kjs (redundant pocketome entry)

Contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 cF
V
2
6
V
2
7
A
2
8
R
3
9
I
4
1
W
4
3
N
4
4
V
4
5
D
4
8
M
4
9
F
5
2
R
5
3
T
8
0
S
8
3
I
8
4
P
8
5
F
8
8
L
9
1
R
9
4
I
1
5
4
Y
1
6
0
T
1
7
8
R
2
5
7
C
4
0
3
H
4
0
4
R
4
2
3
S
4
2
4
D
4
2
6
G
4
3
0
N
4
3
4
H
4
6
4
Y
4
6
6
[2]3kjs.c dq1 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nap
[1]3iro.b 2cy 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ndp
[1]3inv.b c50 23 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ndp.ump
[2]3clb.c tmq 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nap
[2]3cl9.a mtx.ump 53 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nap
[1]3irm.b 1cy 17 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2h2q.b none . . . - - . . . . . . . . . . . . . . . . . . . . . . . . . . . nap-du

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
Similar entries
Feedback