DRTS_TOXGO_1_610

Bifunctional dihydrofolate reductase-thymidylate synthase

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DRTS_TOXGO):D: DHFR (8:10,23,31,32,35,36,86:88,91,94,97,151,172)8:10,23,31,32,35,36,86:88,91,94,97,151,172
Cofactors (cF):ndp

Full PDB list

4eil,4ky4,4kya,5t0l (redundant pocketome entry)

Contact map

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ligand
A1 cF
V
8
V
9
A
1
0
L
2
3
D
3
1
F
3
2
F
3
5
S
3
6
S
8
6
M
8
7
P
8
8
F
9
1
L
9
4
R
9
7
V
1
5
1
T
1
7
2
[1]4kya.b fol 32 . . . . . . . . . . . . . . . . ndp
[1]4ky4.a 04j 32 . . . . . . . . . . . . . . . . ndp
[1]5t0l.b 73x 22 . . . . . . . . . . . . . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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