DRTS_PLAVI_1_238

Bifunctional dihydrofolate reductase-thymidylate synthase

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DRTS_PLAVI):D: DHFR (13:15,45,53,54,57,117,120,121,173,194)
R: Substrate binding (13,14)
13:15,45,53,54,57,117,120,121,173,194
Cofactors (cF):ndp

Full PDB list

2bl9,2bla,2blb,2blc

Contact map

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ligand
A1 cF
I
1
3
C
1
4
A
1
5
L
4
5
D
5
3
M
5
4
F
5
7
S
1
1
7
S
1
2
0
I
1
2
1
I
1
7
3
T
1
9
4
[1]2blb.a cp7 16 . . . . . . . . . . . . ndp
[1]2bl9.a cp6 17 . . . . . . . . . . . . ndp
[1]2blc.a cp7 16 . . . . . . . N . . . . ndp
[1]2bla.a cp6 17 . . . . . . . N . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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