DRTS_PLAFK_1_608

Bifunctional dihydrofolate reductase-thymidylate synthase

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DRTS_PLAFK):D: DHFR (14:16,46,54,55,58,59,104,108,111:113,116,119,122,164,170,185)
R: Substrate binding (14,15)
14:16,46,54,55,58,59,104,108,111:113,116,119,122,164,170,185
Cofactors (cF):nap.ump/ndp/ndp.ump

Full PDB list

1j3i,1j3j,1j3k,3dg8,3dga,3jsu,3qg2,3qgt,3um5,3um6,3um8,4dp3,4dpd,4dph

Contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 cF
I
1
4
C
1
5
A
1
6
L
4
6
D
5
4
M
5
5
F
5
8
R
5
9
M
1
0
4
N
1
0
8
S
1
1
1
I
1
1
2
P
1
1
3
F
1
1
6
L
1
1
9
R
1
2
2
I
1
6
4
Y
1
7
0
T
1
8
5
[1]3jsu.a ka5 25 . . . . . . . . . . . . . . . . L . . ndp.ump
[1]4dp3.a mmv 26 . . . . . . . . . . . . . . . . L . . ndp
[1]4dph.a p65 23 . . . . . . . . . . . . . . . . L . . ndp
[1]1j3i.a wra 24 . . . . . . . C . S . . . . . . . . . ndp
[1]4dpd.a dhf 32 . . . . . . . C . S . . . . . . . . . nap.ump
[1]4dpd.b none . . . . . . . C . S . . . . . . . . .
[1]3dga.a rj1 18 . . . . . . . C . S . . . . . . . . . ndp
[1]3dg8.b rj6 17 . . . . . . . . . . . . . . . . L . . ndp
[1]3um8.a 1cy 17 . . . . . . . C . S . . . . . . . . . ndp
[1]3um6.a 1cy 17 . . V . . . . C . T . . . . . . . . . ndp.ump
[1]1j3j.a cp6 17 . . . . . . . . . . . . . . . . . . . ndp
[1]1j3k.a wra 24 . . . . . . . . . . . . . . . . L . . ndp
[1]3qg2.a cp6 17 . . . . . . . . . . . . . . . . L . . ndp.ump
[1]3qgt.a cp6 17 . . . . . . . C . S . . . . . . . . . ndp.ump
[1]3um5.a cp6 17 . . V . . . . C . T . . . . . . . . . ndp.ump

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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