DPYD_PIG_1_1025_uracil

Dihydropyrimidine dehydrogenase [NADP(+)] [Dihydropyrimidine dehydrogenase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DPYD_PIG):R: Substrate binding (668,670)
R: Substrate binding (736,737)
609,611:613,671:673,675,764
609,611:613,668,670:673,675,736,737,764
Cofactors (cF):fmn

Full PDB list

1gt8,1gte,1gth,1h7w,1h7x (redundant pocketome entry)

Contact map

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ligand
A1 cF
N
6
0
9
E
6
1
1
L
6
1
2
I
6
1
3
N
6
6
8
S
6
7
0
C
6
7
1
P
6
7
2
H
6
7
3
M
6
7
5
N
7
3
6
T
7
3
7
G
7
6
4
[1]1gt8.b uaa 12 . . . . . . . . . . . . . fmn
[1]1gth.a idh 8 . . . . . . * . . . . . . fmn
[1]1gth.c iur 9 . . . . . . . . . . . . . fmn
[1]1gth.d ura 8 . . . . . . . . . . . . . fmn
[1]1h7w.a none . . . . . . . . . . . . . fmn
[1]1h7x.a urf 9 . . . . . . A . . - . . . fmn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
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[xml] Download XML file
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