DNMT1_MOUSE_730_1609

DNA (cytosine-5)-methyltransferase 1 [Class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DNMT1_MOUSE):D: SAM-dependent MTase C5-type (1148:1150,1152:1154,1171:1173,1192:1194,1226:1229,1233,1235,1247,1250,1269:1271,1313,1315,1530,1579:1582)
R: Catalytic (1148:1150,1152:1154,1171:1173,1192:1194,1226:1229,1233,1235,1247,1250,1269:1271,1313,1315,1530,1579:1582)
1148:1150,1152:1154,1171:1173,1192:1194,1226:1229,1233,1235,1247,1250,1269:1271,1313,1315,1530,1579:1582

Full PDB list

3av4,3av5,3av6,3pt6,3pt9,4da4 (redundant pocketome entry)

Contact map

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ligand
A1
F
1
1
4
8
S
1
1
4
9
G
1
1
5
0
G
1
1
5
2
G
1
1
5
3
L
1
1
5
4
E
1
1
7
1
M
1
1
7
2
W
1
1
7
3
E
1
1
9
2
D
1
1
9
3
C
1
1
9
4
G
1
2
2
6
P
1
2
2
7
P
1
2
2
8
C
1
2
2
9
S
1
2
3
3
M
1
2
3
5
K
1
2
4
7
L
1
2
5
0
E
1
2
6
9
N
1
2
7
0
V
1
2
7
1
R
1
3
1
3
R
1
3
1
5
T
1
5
3
0
G
1
5
7
9
N
1
5
8
0
A
1
5
8
1
V
1
5
8
2
[1]4da4.a c49,sah 47 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3av6.a sam 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3av4.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3pt6.a sah 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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