DNMT1_HUMAN_1129_1600_catalytic

DNA (cytosine-5)-methyltransferase 1 [Class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (DNMT1_HUMAN):D: SAM-dependent MTase C5-type (1145:1147,1149:1151,1167:1170,1189:1191,1223,1225,1247,1266,1578:1580)
R: Catalytic (1145:1147,1149:1151,1167:1170,1189:1191,1223,1225,1247,1266,1578:1580)
1145:1147,1149:1151,1167:1170,1189:1191,1223,1225,1247,1266,1578:1580

Full PDB list

3swr,4wxx,4yoc

Contact map

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ligand
A1
F
1
1
4
5
S
1
1
4
6
G
1
1
4
7
G
1
1
4
9
G
1
1
5
0
L
1
1
5
1
I
1
1
6
7
E
1
1
6
8
M
1
1
6
9
W
1
1
7
0
E
1
1
8
9
D
1
1
9
0
C
1
1
9
1
G
1
2
2
3
P
1
2
2
5
L
1
2
4
7
E
1
2
6
6
N
1
5
7
8
A
1
5
7
9
V
1
5
8
0
[1]3swr.a sfg 27 . . . . . . . . . . . . . . . . . . . .
[1]4wxx.a sah 26 . . . . . . . . . . . . . . . . . . . .
[1]4yoc.a none . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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