DHI1_MOUSE_25_291

Corticosteroid 11-beta-dehydrogenase isozyme 1 [Short-chain dehydrogenases/reductases (SDR) family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains homodimer
 • A1 (DHI1_MOUSE):121,124:126,170:172,177,180,183,215:217,222,223,226,227,231,233121,124:126,170:172,177,180,183,215:217,222,223,226,227,231,233
 • A2 (DHI1_MOUSE):280,283,284280,283,284
Cofactors (cF):ndp

Full PDB list

1y5m,1y5r,3gmd,4k26,4nmh

Contact map

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ligand
A1 A2 cF
I
1
2
1
T
1
2
4
S
1
2
5
L
1
2
6
S
1
7
0
L
1
7
1
A
1
7
2
Q
1
7
7
I
1
8
0
Y
1
8
3
L
2
1
5
G
2
1
6
L
2
1
7
T
2
2
2
A
2
2
3
E
2
2
6
I
2
2
7
I
2
3
1
A
2
3
3
S
2
8
0
Y
2
8
3
Y
2
8
4
[1]3gmd.c 2m3 26 . . . . . . . Y V . . . . . . A V V . . . . ndp
[1]4nmh.a 2kg 25 . . . . . . . Y V . . . . . . . . . . . . . ndp
[1]1y5r.b c0r 25 . . . . . . . . . . . . . . . . . . . . . . ndp
[1]4k26.a sff 19 . . . . . . . . . . . . . . . . . . . . . . ndp
[1]1y5m.a oct 8 . . . . . . . . . . . . . . . . . . . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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