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DCLK1_HUMAN_370_649

Serine/threonine-protein kinase DCLK1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

Composition of the binding site

Protein chains homodimer [domain annotation]
A1 (DCLK1_HUMAN):D: Protein kinase (396:399, 402, 404, 406, 417, 419, 449, 465:469, 471, 472, 475, 515, 516, 518, 533)396:399, 402, 404, 406, 417, 419, 449, 465:469, 471, 472, 475, 515, 516, 518, 533
A2 (DCLK1_HUMAN):D: Protein kinase (427)427
Metals (Me):Mg

Full PDB list

5jzj, 5jzn

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 A2 Me
I
3
9
6
G
3
9
7
G
3
9
9
A
4
0
2
V
4
0
4
E
4
0
6
A
4
1
7
K
4
1
9
V
4
4
9
M
4
6
5
E
4
6
6
L
4
6
7
V
4
6
8
G
4
7
1
D
4
7
2
D
4
7
5
E
5
1
5
N
5
1
6
L
5
1
8
D
5
3
3
R
4
2
7
[1]5jzj.b an227 . . . . . . . . . . . . . . . . . . . . . Mg
[1]5jzn.b gui42 . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 A2 Me
I
3
9
6
G
3
9
7
D
3
9
8
G
3
9
9
A
4
0
2
V
4
0
4
E
4
0
6
A
4
1
7
K
4
1
9
V
4
4
9
M
4
6
5
E
4
6
6
L
4
6
7
V
4
6
8
K
4
6
9
G
4
7
1
D
4
7
2
D
4
7
5
E
5
1
5
N
5
1
6
L
5
1
8
D
5
3
3
R
4
2
7
[1]5jzj.b . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]5jzn.b . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
5jzj.b:an2
5jzn.b:gui
[1] 5jzj.b
0
1.0
[1] 5jzn.b 0.2
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
5jzj.b
5jzn.b
[1] 5jzj.b
0
.05
[1] 5jzn.b .05
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5jzj.b
5jzn.b
[1] 5jzj.b
0
0.9
[1] 5jzn.b 0.9
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5jzj.b
5jzn.b
[1] 5jzj.b
0
1.1
[1] 5jzn.b 1.1
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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