DCIP_AZOBR_2_545_catalytic

Indole-3-pyruvate decarboxylase [TPP enzyme family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains homodimer[show domain annotation]
 • A1 (DCIP_AZOBR):R: Thiamine pyrophosphate binding (382,402:404,428:431,434,456,458:460)
282,283,380,381,461,462,465,532,536
282,283,380:382,402:404,428:431,434,456,458:462,465,532,536
 • A2 (DCIP_AZOBR):22:25,48,71,74,112,11322:25,48,71,74,112,113
Metals (Me):Mg

Full PDB list

2nxw,2q5j,2q5l,2q5o,2q5q

Contact map

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ligand
A1 A2 Me
D
2
8
2
T
2
8
3
M
3
8
0
G
3
8
1
D
3
8
2
A
4
0
2
G
4
0
3
M
4
0
4
G
4
2
8
D
4
2
9
G
4
3
0
A
4
3
1
M
4
3
4
N
4
5
6
S
4
5
8
W
4
5
9
E
4
6
0
M
4
6
1
L
4
6
2
F
4
6
5
F
5
3
2
Q
5
3
6
I
2
2
P
2
3
G
2
4
D
2
5
E
4
8
T
7
1
A
7
4
H
1
1
2
H
1
1
3
[1]2q5q.a kpv,tpw 40 . . . . . . . . . . . . . . . . . . . . . - . . . . . . . . . Mg
[1]2q5l.a r1t,s1t 58 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - Mg
[1]2nxw.a tpp 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - Mg
[1]2q5j.a tpw 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - Mg
[1]2q5o.a ppy,tpw 38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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