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DAPP1_HUMAN_148_273

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (DAPP1_HUMAN):D: PH (173, 175:178, 180, 182, 184, 195, 197, 205, 206, 235)173, 175:178, 180, 182, 184, 195, 197, 205, 206, 235

Full PDB list

1fao, 1fb8

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
K
1
7
3
G
1
7
5
G
1
7
6
L
1
7
7
V
1
7
8
T
1
8
0
K
1
8
2
R
1
8
4
Y
1
9
5
K
1
9
7
I
2
0
5
R
2
3
5
[1]1fao.a 4ip28 . . . . . . . . . . . .
[1]1fb8.a none . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
K
1
7
3
G
1
7
5
G
1
7
6
L
1
7
7
V
1
7
8
T
1
8
0
K
1
8
2
R
1
8
4
Y
1
9
5
K
1
9
7
I
2
0
5
R
2
0
6
R
2
3
5
[1]1fao.a . . . . . . . . . . . . .
[1]1fb8.a . . . * . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1fao.a:4ip
1fb8.a is apo
[1] 1fao.a
0
-
[1] 1fb8.a 3.2
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1fao.a
1fb8.a
[1] 1fao.a
0
.25
[1] 1fb8.a .25
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1fao.a
1fb8.a
[1] 1fao.a
0
0.8
[1] 1fb8.a 0.8
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1fao.a
1fb8.a
[1] 1fao.a
0
1.4
[1] 1fb8.a 1.4
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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