If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

DAPK2_HUMAN_10_297

Death-associated protein kinase 2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (DAPK2_HUMAN):D: Protein kinase (29:35, 37, 50, 52, 87, 103:106, 149, 154, 156, 170, 171)29:35, 37, 50, 52, 87, 103:106, 149, 154, 156, 170, 171

Full PDB list

1zws, 2a27, 2a2a, 2cke, 2ya9, 2yaa, 2yab (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
2
9
G
3
0
S
3
1
G
3
2
Q
3
3
A
3
5
V
3
7
A
5
0
K
5
2
I
8
7
E
1
0
4
L
1
0
5
V
1
0
6
N
1
5
4
M
1
5
6
I
1
7
0
D
1
7
1
[1]2a2a.b none . . . . . . . . . . . . . . . . .
[1]2cke.b iqu17 . . . . . . . . . . . . . . . . .
[1]2yaa.a atp31 . . . . . . . . . . . . . . . . .
[1]2yab.b amp23 . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
2
9
G
3
0
S
3
1
G
3
2
Q
3
3
F
3
4
A
3
5
V
3
7
A
5
0
K
5
2
I
8
7
L
1
0
3
E
1
0
4
L
1
0
5
V
1
0
6
D
1
4
9
N
1
5
4
M
1
5
6
I
1
7
0
D
1
7
1
[1]2a2a.b . . . . * . . . . . . . . . . . . . . .
[1]2cke.b . . . . . . . . . . . . . . . . . . . .
[1]2yaa.a . . . . . . . . . . . . . . . . . . . .
[1]2yab.b . . . . . . . . . * . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2a2a.b is apo
2cke.b:iqu
2yaa.a:atp
2yab.b:amp
[1] 2a2a.b
-
0 1.7 0.1
[1] 2cke.b -
0
0.3 0
[1] 2yaa.a - 0.1
0
0
[1] 2yab.b - 0.1 0.6
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2a2a.b
2cke.b
2yaa.a
2yab.b
[1] 2a2a.b
0
.08 .10 .13
[1] 2cke.b .08
0
.02 .05
[1] 2yaa.a .10 .02
0
.03
[1] 2yab.b .13 .05 .03
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2a2a.b
2cke.b
2yaa.a
2yab.b
[1] 2a2a.b
0
0.7 0.5 0.8
[1] 2cke.b 0.7
0
0.6 0.9
[1] 2yaa.a 0.5 0.6
0
0.7
[1] 2yab.b 0.8 0.9 0.7
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2a2a.b
2cke.b
2yaa.a
2yab.b
[1] 2a2a.b
0
0.8 1.3 1.4
[1] 2cke.b 0.8
0
1.1 1.1
[1] 2yaa.a 1.3 1.1
0
1.0
[1] 2yab.b 1.4 1.1 1.0
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...