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CYH3_HUMAN_258_394

Cytohesin-3

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CYH3_HUMAN):D: PH (273, 275:281, 283, 285, 296, 306, 344, 355, 356)
R: Phosphatidylinositol 3,4,5-trisphosphate binding (273, 275:281)
273, 275:281, 283, 285, 296, 306, 344, 355, 356

Full PDB list

1fgy, 1fgz, 1fhw, 1fhx, 1u2b, 2r09, 2r0d, 4kax (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
K
2
7
3
G
2
7
6
G
2
7
7
R
2
7
8
V
2
7
9
T
2
8
1
K
2
8
3
R
2
8
5
Y
2
9
6
R
3
0
6
K
3
4
4
N
3
5
5
H
3
5
6
[1]1fgy.a 4ip28 . . . . . . . . . . . . .
[1]1fgz.a none . . . . . . . . . . . . .
[1]1fhw.a i5p32 . - . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
K
2
7
3
G
2
7
5
G
2
7
6
G
2
7
7
R
2
7
8
V
2
7
9
K
2
8
0
T
2
8
1
K
2
8
3
R
2
8
5
Y
2
9
6
R
3
0
6
K
3
4
4
N
3
5
5
H
3
5
6
[1]1fgy.a . - . . . * . . . . . . . . .
[1]1fgz.a . - . . . * . . * . . . . . .
[1]1fhw.a . . - . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1fgy.a:4ip
1fgz.a is apo
1fhw.a:i5p
[1] 1fgy.a
0.2
- 3.5
[1] 1fgz.a 1.0
-
3.4
[1] 1fhw.a 0.2 -
0.3
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1fgy.a
1fgz.a
1fhw.a
[1] 1fgy.a
0
.22 .23
[1] 1fgz.a .22
0
.22
[1] 1fhw.a .23 .22
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.9 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1fgy.a
1fgz.a
1fhw.a
[1] 1fgy.a
0
0.6 1.3
[1] 1fgz.a 0.6
0
1.4
[1] 1fhw.a 1.3 1.4
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1fgy.a
1fgz.a
1fhw.a
[1] 1fgy.a
0
0.9 1.4
[1] 1fgz.a 0.9
0
1.4
[1] 1fhw.a 1.4 1.4
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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