If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

CYH2_HUMAN_53_252

Cytohesin-2

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CYH2_HUMAN):D: SEC7 (148, 151:157, 159, 160, 163, 164, 190, 193, 196, 197)
243:246
148, 151:157, 159, 160, 163, 164, 190, 193, 196, 197, 243:246

Full PDB list

1pbv, 1r8m, 1r8q, 1r8s, 1s9d, 4jmi, 4jmo, 4jwl, 4jxh, 4l5m, 4z21 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
1
4
8
F
1
5
1
R
1
5
2
L
1
5
3
P
1
5
4
G
1
5
5
I
1
6
0
M
1
6
4
F
1
9
0
I
1
9
3
N
1
9
6
T
1
9
7
F
2
4
3
K
2
4
4
I
2
4
5
P
2
4
6
[1]1r8m.e none . . . . . . . . Y . . . . . . .
[1]4jmo.a jaf21 . . . . . . . . . . . . . . . .
[1]4z21.a none . . . . . . . . . . . . . . . .
[2]1r8q.e IG12 . . . . . . . . Y . . . . . . .
[2]1r8s.e G4 . . . . . . . . Y . . . . . . .
[2]1s9d.e G4 . . . . . . . . Y . . . . . . .
[3]4jxh.a hrc19 . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
1
4
8
F
1
5
1
R
1
5
2
L
1
5
3
P
1
5
4
G
1
5
5
E
1
5
6
A
1
5
7
K
1
5
9
I
1
6
0
M
1
6
3
M
1
6
4
F
1
9
0
I
1
9
3
N
1
9
6
T
1
9
7
F
2
4
3
K
2
4
4
I
2
4
5
P
2
4
6
[1]1r8m.e . . . * . . . . . . . . Y . . . . . * .
[1]4jmo.a . . . * . . . . . . . . . . . . . . * .
[1]4z21.a . . . * . . . . . . . . . . . . . . . .
[2]1r8q.e . . . * * . . . . * . . Y . . . . . . .
[2]1r8s.e . . . * * . K . . * . . Y . . . . . . .
[2]1s9d.e . . . * * . . . . * . . Y . . . . . . .
[3]4jxh.a . . . . . . . . . . . . . . . . . . * .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1r8m.e is apo
4jmo.a:jaf
4z21.a is apo
1r8q.e:IG
1r8s.e:G
1s9d.e:G
4jxh.a:hrc
[1] 1r8m.e
-
1.1 - 2.3 0.3 0.1 3.1
[1] 4jmo.a -
0
- 1.9 0 0 2.5
[1] 4z21.a - 0.6
-
0.8 0.3 0.1 3.6
[2] 1r8q.e - 6.0 -
0
0.1 0 6.4
[2] 1r8s.e - 6.6 - 0
0
0 7.0
[2] 1s9d.e - 6.2 - 0 0.1
0
6.8
[3] 4jxh.a - 1.5 - 3.1 0 0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (3 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1r8m.e
4jmo.a
4z21.a
1r8q.e
1r8s.e
1s9d.e
4jxh.a
[1] 1r8m.e
0
.13 .12 .38 .44 .40 .26
[1] 4jmo.a .13
0
.18 .41 .45 .43 .20
[1] 4z21.a .12 .18
0
.28 .34 .31 .33
[2] 1r8q.e .38 .41 .28
0
.07 .03 .57
[2] 1r8s.e .44 .45 .34 .07
0
.04 .62
[2] 1s9d.e .40 .43 .31 .03 .04
0
.60
[3] 4jxh.a .26 .20 .33 .57 .62 .60
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.9 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1r8m.e
4jmo.a
4z21.a
1r8q.e
1r8s.e
1s9d.e
4jxh.a
[1] 1r8m.e
0
1.0 0.9 2.6 2.8 2.7 1.4
[1] 4jmo.a 1.0
0
0.8 3.2 3.4 3.3 1.2
[1] 4z21.a 0.9 0.8
0
2.9 3.1 3.0 1.3
[2] 1r8q.e 2.6 3.2 2.9
0
0.4 0.3 3.2
[2] 1r8s.e 2.8 3.4 3.1 0.4
0
0.4 3.4
[2] 1s9d.e 2.7 3.3 3.0 0.3 0.4
0
3.3
[3] 4jxh.a 1.4 1.2 1.3 3.2 3.4 3.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1r8m.e
4jmo.a
4z21.a
1r8q.e
1r8s.e
1s9d.e
4jxh.a
[1] 1r8m.e
0
1.3 1.5 2.8 2.9 2.9 1.9
[1] 4jmo.a 1.3
0
1.3 3.4 3.5 3.5 1.8
[1] 4z21.a 1.5 1.3
0
3.1 3.2 3.2 1.9
[2] 1r8q.e 2.8 3.4 3.1
0
0.6 0.4 3.5
[2] 1r8s.e 2.9 3.5 3.2 0.6
0
0.5 3.6
[2] 1s9d.e 2.9 3.5 3.2 0.4 0.5
0
3.6
[3] 4jxh.a 1.9 1.8 1.9 3.5 3.6 3.6
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...