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CYH2_HUMAN_252_378

Cytohesin-2

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CYH2_HUMAN):D: PH (268, 270:272, 278, 280, 291, 301, 339, 350, 351)
R: Phosphatidylinositol 1,4,5-trisphosphate binding (268, 270:272)
268, 270:272, 278, 280, 291, 301, 339, 350, 351

Full PDB list

1u27, 1u29

Pocket contact map

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PDB.ch
   
ligand
A1
K
2
6
8
G
2
7
0
G
2
7
1
K
2
7
8
R
2
8
0
Y
2
9
1
R
3
0
1
K
3
3
9
N
3
5
0
H
3
5
1
[1]1u27.a 4ip28 . . . . . . . . . .
[1]1u29.a i3p24 . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
K
2
6
8
G
2
7
0
G
2
7
1
G
2
7
2
K
2
7
8
R
2
8
0
Y
2
9
1
R
3
0
1
K
3
3
9
N
3
5
0
H
3
5
1
[1]1u27.a . . . . . . . . . . .
[1]1u29.a . . . . . . . . . * .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1u27.a:4ip
1u29.a:i3p
[1] 1u27.a
0
0.4
[1] 1u29.a 1.3
0.2
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1u27.a
1u29.a
[1] 1u27.a
0
.13
[1] 1u29.a .13
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1u27.a
1u29.a
[1] 1u27.a
0
1.3
[1] 1u29.a 1.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1u27.a
1u29.a
[1] 1u27.a
0
1.3
[1] 1u29.a 1.3
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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