CXCR4_HUMAN_1_319_TM

C-X-C chemokine receptor type 4 [G-protein coupled receptor 1 family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (CXCR4_HUMAN):R: Chemokine binding (94,97)
R: Chemokine binding (113,116,117)
R: Chemokine binding, important for signaling and HIV-1 coreceptor activity (186:190)
R: Involved in dimerization (191:193,196,197,199:201,204,209)
R: Involved in dimerization (266)
27,32,98,102,112,171,183,185,259,262,263,281,284,285,288
27,32,94,97,98,102,112,113,116,117,171,183,185:193,196,197,199:201,204,209,259,262,263,266,281,284,285,288

Full PDB list

3odu,3oe0,3oe6,3oe8,3oe9,4rws (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
P
2
7
E
3
2
W
9
4
D
9
7
A
9
8
W
1
0
2
V
1
1
2
H
1
1
3
Y
1
1
6
T
1
1
7
D
1
7
1
R
1
8
3
I
1
8
5
C
1
8
6
D
1
8
7
R
1
8
8
F
1
8
9
Y
1
9
0
P
1
9
1
N
1
9
2
D
1
9
3
V
1
9
6
V
1
9
7
F
1
9
9
Q
2
0
0
F
2
0
1
I
2
0
4
I
2
0
9
I
2
5
9
D
2
6
2
S
2
6
3
L
2
6
6
H
2
8
1
I
2
8
4
S
2
8
5
E
2
8
8
[1]3oe0.a RRalnCYQKdprPYRcirCRGdpr 150 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3odu.a itd,olc 49 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3odu.b itd,ola 47 - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4rws.a LGASCH-QL-P 63 . . . . . . . . . . . . . . C . . . . . . . . . . . . . . . . . . . . .
[1]3oe8.a itd 27 . - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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