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CSK_HUMAN_180_450

Tyrosine-protein kinase CSK [Protein kinase superfamily. Tyr protein kinase family. CSK subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CSK_HUMAN):D: Protein kinase (201, 202, 209, 220, 222, 266:269, 272, 273, 276, 318, 319, 321, 331, 332)201, 202, 209, 220, 222, 266:269, 272, 273, 276, 318, 319, 321, 331, 332

Full PDB list

1byg, 1k9a, 3d7t (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
2
0
1
G
2
0
2
V
2
0
9
A
2
2
0
K
2
2
2
T
2
6
6
Y
2
6
8
M
2
6
9
G
2
7
2
S
2
7
3
R
3
1
8
L
3
2
1
S
3
3
1
D
3
3
2
[1]1k9a.a none . . . . . . . . . . . . . .
[1]3d7t.a stu35 . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
2
0
1
G
2
0
2
V
2
0
9
A
2
2
0
K
2
2
2
T
2
6
6
E
2
6
7
Y
2
6
8
M
2
6
9
G
2
7
2
S
2
7
3
D
2
7
6
R
3
1
8
N
3
1
9
L
3
2
1
S
3
3
1
D
3
3
2
[1]1k9a.a . . . . . . . . . . . . . . . . .
[1]3d7t.a . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1k9a.a is apo
3d7t.a:stu
[1] 1k9a.a
-
0.5
[1] 3d7t.a -
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1k9a.a
3d7t.a
[1] 1k9a.a
0
.02
[1] 3d7t.a .02
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1k9a.a
3d7t.a
[1] 1k9a.a
0
0.9
[1] 3d7t.a 0.9
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1k9a.a
3d7t.a
[1] 1k9a.a
0
2.1
[1] 3d7t.a 2.1
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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