CSF1R_HUMAN_539_921

Macrophage colony-stimulating factor 1 receptor [Protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (CSF1R_HUMAN):D: Protein kinase (586:589,596,614,616,633,636,637,640,647,661,663:670,673,774:777,782,783,785,794:797,800,801)
R: Activation loop (796,797,800,801)
550,586:589,596,614,616,633,636,637,640,647,661,663:670,673,774:777,782,783,785,794:797,800,801

Full PDB list

2i0v,2i0y,2i1m,2ogv,3bea,3dpk,3krj,3krl,3lcd,3lco,4hw7,4r7h,4r7i (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
W
5
5
0
K
5
8
6
T
5
8
7
L
5
8
8
G
5
8
9
V
5
9
6
A
6
1
4
K
6
1
6
E
6
3
3
I
6
3
6
M
6
3
7
L
6
4
0
V
6
4
7
V
6
6
1
T
6
6
3
E
6
6
4
Y
6
6
5
C
6
6
6
C
6
6
7
Y
6
6
8
G
6
6
9
D
6
7
0
N
6
7
3
C
7
7
4
I
7
7
5
H
7
7
6
R
7
7
7
R
7
8
2
N
7
8
3
L
7
8
5
I
7
9
4
G
7
9
5
D
7
9
6
F
7
9
7
A
8
0
0
R
8
0
1
[2]4hw7.a 64m 30 - . . . . . . . . . . . . . . . . . T . . . . . . . . . . . . . . . . .
[1]3krj.a krj 28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3krl.a krl 29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]3lco.a lc0 33 - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4r7h.a p31 29 . . . . . . . . . . . . . . . . . . T . . . . . . . . . . . . . . . . .
[1]2i0v.a 6c3 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3dpk.a 8c5 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]3lcd.a bdy 36 - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3bea.a ixh 38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]4r7i.a sti 37 - . . . . . . . . . . . . . . . . . T . . . . . . . . . . . . . . . . .
[1]2ogv.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2i1m.a 5cn 25 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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