If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

CRYM_MOUSE_1_313

Ketimine reductase mu-crystallin [Ornithine cyclodeaminase/mu-crystallin family]

Composition of the binding site

Protein chains monomer
A1 (CRYM_MOUSE):47, 49, 58:60, 62, 75, 77, 79, 91, 115, 118, 205, 228:230, 232, 256, 292, 29347, 49, 58:60, 62, 75, 77, 79, 91, 115, 118, 205, 228:230, 232, 256, 292, 293
Cofactors (cF):ndp

Full PDB list

4bv8, 4bv9, 4bva (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 cF
R
4
7
V
4
9
F
5
8
L
5
9
G
6
0
M
6
2
K
7
5
V
7
7
F
7
9
H
9
1
T
1
1
5
R
1
1
8
S
2
2
8
R
2
2
9
P
2
3
0
W
2
3
2
E
2
5
6
G
2
9
3
[1]4bv9.b none . . . . . . . . . . . . . . . . . . ndp
[1]4bva.b t323 . . . . . . . . . . . . . . . . . . ndp
[2]4bv9.a pyr6 . . . . . . . . . . . . . . . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 cF
R
4
7
V
4
9
F
5
8
L
5
9
G
6
0
M
6
2
K
7
5
V
7
7
F
7
9
H
9
1
T
1
1
5
R
1
1
8
M
2
0
5
S
2
2
8
R
2
2
9
P
2
3
0
W
2
3
2
E
2
5
6
L
2
9
2
G
2
9
3
[1]4bv9.b . . . . . . . . . . . . . . . . . . . . ndp
[1]4bva.b . . . . . . . . . . . . . . . . . . . . ndp
[2]4bv9.a . . . . . . . . * . . . . . * . . . . . ndp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4bv9.b is apo
4bva.b:t3
4bv9.a:pyr
[1] 4bv9.b
-
1.5 0.1
[1] 4bva.b -
0.1
0.1
[2] 4bv9.a - 7.8
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4bv9.b
4bva.b
4bv9.a
[1] 4bv9.b
0
.08 .32
[1] 4bva.b .08
0
.39
[2] 4bv9.a .32 .39
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4bv9.b
4bva.b
4bv9.a
[1] 4bv9.b
0
0.8 0.5
[1] 4bva.b 0.8
0
1.0
[2] 4bv9.a 0.5 1.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4bv9.b
4bva.b
4bv9.a
[1] 4bv9.b
0
1.1 1.4
[1] 4bva.b 1.1
0
1.7
[2] 4bv9.a 1.4 1.7
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...