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CRFR1_HUMAN_112_401_TM

Corticotropin-releasing factor receptor 1 [G-protein coupled receptor 2 family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CRFR1_HUMAN):R: Important for antagonist binding (309, 312, 313, 315, 316, 319)
191, 232, 235, 236, 239, 345, 348, 349, 352, 356
191, 232, 235, 236, 239, 309, 312, 313, 315, 316, 319, 345, 348, 349, 352, 356

Full PDB list

4k5y, 4z9g (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
F
1
9
1
F
2
3
2
M
2
3
5
G
2
3
9
L
3
0
9
N
3
1
2
F
3
1
3
T
3
4
5
L
3
4
9
L
3
5
2
Y
3
5
6
[1]4k5y.a 1q524 . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
F
1
9
1
F
2
3
2
M
2
3
5
F
2
3
6
G
2
3
9
L
3
0
9
N
3
1
2
F
3
1
3
F
3
1
5
L
3
1
6
I
3
1
9
T
3
4
5
L
3
4
8
L
3
4
9
L
3
5
2
Y
3
5
6
[1]4k5y.a . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)







[show 3D visualization]

[ENTRY 2D visualization]

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