CRBN_HUMAN_318_430

Protein cereblon [CRBN family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (CRBN_HUMAN):D: CULT (351:353,377:380,386,400,402)
R: Thalidomide binding (378:380,386)
351:353,377:380,386,400,402
Metals (Me):Zn

Full PDB list

3wx1,3wx2,4tz4,4tzc,4tzu,5fqd (redundant pocketome entry)

Contact map

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ligand
A1 Me
N
3
5
1
P
3
5
2
H
3
5
3
E
3
7
7
H
3
7
8
S
3
7
9
W
3
8
0
W
3
8
6
W
4
0
0
F
4
0
2
[1]4tzu.a y70 20 - - - V . . . . . . Zn
[1]4tzc.c ef2 19 - - - V . . . . . . Zn
[1]3wx1.a none . . . V . . . . . . Zn
[1]5fqd.b lvy 19 . . . . . . . . . . Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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