If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

CPT2_RAT_28_658

Carnitine O-palmitoyltransferase 2, mitochondrial [Carnitine/choline acetyltransferase family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CPT2_RAT):R: Coenzyme A binding (453, 464)
135, 176, 210, 212, 372, 376:378, 381, 487:490, 493, 499, 502, 543, 547, 590:593
135, 176, 210, 212, 372, 376:378, 381, 453, 464, 487:490, 493, 499, 502, 543, 547, 590:593
Cofactors (cF):bog/buj/plm

Full PDB list

2deb, 2fw3, 2fyo, 2h4t, 2rcu, 4ep9, 4eph, 4eyw (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 cF
F
1
7
6
L
2
1
2
H
3
7
2
D
3
7
6
G
3
7
7
V
3
7
8
L
3
8
1
K
4
5
3
D
4
6
4
E
4
8
7
S
4
8
8
C
4
8
9
S
4
9
0
A
4
9
3
T
4
9
9
I
5
0
2
T
5
4
3
A
5
4
7
S
5
9
0
T
5
9
1
L
5
9
2
N
5
9
3
[1]2deb.b none . . . . . . . . . . . . . . . . . . . . . . plm
[1]2h4t.a d1212 . . . . . . . . . . . . . . . . . T . . . .
[1]2rcu.b none . . . . . . . . . . . . . . . . . . . . . . buj
[1]4ep9.a 0rd34 . . . . . . . . . . . . . . . . . . . . . . plm
[1]4eph.a 0rk35 . . . . . . . . . . . . . . . . . . . . . . bog
[1]4eyw.a l0r28 . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 cF
M
1
3
5
F
1
7
6
Y
2
1
0
L
2
1
2
H
3
7
2
D
3
7
6
G
3
7
7
V
3
7
8
L
3
8
1
K
4
5
3
D
4
6
4
E
4
8
7
S
4
8
8
C
4
8
9
S
4
9
0
A
4
9
3
T
4
9
9
I
5
0
2
T
5
4
3
A
5
4
7
S
5
9
0
T
5
9
1
L
5
9
2
N
5
9
3
[1]2deb.b * . . . . . . . . . . . . . . . . . . . . . . * plm
[1]2h4t.a . . . . . . . . . . . . . . . . . . . T . . . *
[1]2rcu.b . . . . . . . * . . . . . . . . . . . . . . . * buj
[1]4ep9.a . . . . . . . * . . . . . . . . . . . . . . . . plm
[1]4eph.a . . . . . . . * . . . . . . . . . . . . . . * . bog
[1]4eyw.a . . . . . . . . . . . . . . . . . . . . . . . *

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2deb.b is apo
2h4t.a:d12
2rcu.b is apo
4ep9.a:0rd
4eph.a:0rk
4eyw.a:l0r
[1] 2deb.b
-
0 - 1.4 1.3 0.1
[1] 2h4t.a -
0
- 0.7 1.7 0.2
[1] 2rcu.b - 2.0
-
1.0 1.5 0
[1] 4ep9.a - 2.2 -
0.1
0 0
[1] 4eph.a - 2.4 - 0
0
0
[1] 4eyw.a - 0 - 1.6 1.2
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2deb.b
2h4t.a
2rcu.b
4ep9.a
4eph.a
4eyw.a
[1] 2deb.b
0
.03 .11 .15 .16 .01
[1] 2h4t.a .03
0
.10 .17 .18 .04
[1] 2rcu.b .11 .10
0
.08 .09 .11
[1] 4ep9.a .15 .17 .08
0
.01 .15
[1] 4eph.a .16 .18 .09 .01
0
.16
[1] 4eyw.a .01 .04 .11 .15 .16
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.9 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2deb.b
2h4t.a
2rcu.b
4ep9.a
4eph.a
4eyw.a
[1] 2deb.b
0
0.7 0.9 0.9 0.9 0.5
[1] 2h4t.a 0.7
0
0.9 0.9 0.9 0.4
[1] 2rcu.b 0.9 0.9
0
0.3 0.4 0.8
[1] 4ep9.a 0.9 0.9 0.3
0
0.2 0.8
[1] 4eph.a 0.9 0.9 0.4 0.2
0
0.8
[1] 4eyw.a 0.5 0.4 0.8 0.8 0.8
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2deb.b
2h4t.a
2rcu.b
4ep9.a
4eph.a
4eyw.a
[1] 2deb.b
0
0.9 0.9 1.2 1.2 0.8
[1] 2h4t.a 0.9
0
1.2 1.3 1.3 0.7
[1] 2rcu.b 0.9 1.2
0
0.8 0.9 1.1
[1] 4ep9.a 1.2 1.3 0.8
0
0.3 1.2
[1] 4eph.a 1.2 1.3 0.9 0.3
0
1.2
[1] 4eyw.a 0.8 0.7 1.1 1.2 1.2
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...