CP46A_HUMAN_50_500

Cholesterol 24-hydroxylase [Cytochrome P450 family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer
 • A1 (CP46A_HUMAN):79:81,108:112,121,126,127,219,222,226,227,298,301,302,305,306,367:369,371,472,474,47579:81,108:112,121,126,127,219,222,226,227,298,301,302,305,306,367:369,371,472,474,475
Cofactors (cF):hem
Metals (Me):Fe

Full PDB list

2q9f,2q9g,3mdm,3mdr,3mdt,3mdv,4enh,4fia,4j14

Contact map

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ligand
A1 cF Me
V
7
9
F
8
0
H
8
1
M
1
0
8
Y
1
0
9
R
1
1
0
A
1
1
1
L
1
1
2
F
1
2
1
V
1
2
6
S
1
2
7
L
2
1
9
I
2
2
2
R
2
2
6
N
2
2
7
T
2
9
8
I
3
0
1
A
3
0
2
E
3
0
5
T
3
0
6
A
3
6
7
W
3
6
8
G
3
6
9
F
3
7
1
E
4
7
2
A
4
7
4
T
4
7
5
[1]3mdv.a cl6 25 . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe
[1]4enh.a fvx 22 . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe
[1]3mdt.b vor 25 . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe
[1]3mdm.a fjz 20 . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe
[1]4fia.a 0u9,198 58 . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe
[2]2q9f.a c3s 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe
[2]4j14.a x2n 51 . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe
[1]3mdr.a gjz 10 . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe
[1]2q9g.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . hem Fe

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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