CP2E1_HUMAN_22_493

Cytochrome P450 2E1 [Cytochrome P450 family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (CP2E1_HUMAN):R: Substrate binding (298,299,303)
106,109,115,116,203,206,207,210,239,242,243,364,368,437,478
106,109,115,116,203,206,207,210,239,242,243,298,299,303,364,368,437,478
Cofactors (cF):hem
Metals (Me):Fe

Full PDB list

3e4e,3e6i,3gph,3koh,3lc4,3t3z

Contact map

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ligand
A1 cF Me
F
1
0
6
H
1
0
9
I
1
1
5
F
1
1
6
F
2
0
3
N
2
0
6
F
2
0
7
L
2
1
0
V
2
3
9
V
2
4
2
K
2
4
3
F
2
9
8
A
2
9
9
T
3
0
3
V
3
6
4
L
3
6
8
C
4
3
7
F
4
7
8
[1]3lc4.a lc4 19 . . . . . . . . . . . . . . . . . . hem Fe
[1]3gph.b oid 17 . . . . . . . . . . . . . . . . . . hem Fe
[1]3koh.b oio 15 . . . . . . . . . . . . . . . . . . hem Fe
[1]3t3z.c 9pl 15 . . . . . . . . . . . . . . . . . . hem Fe
[1]3e4e.a 4pz 6 . . . . . . . . . . . . . . . . . . hem Fe
[1]3e6i.a lz1 9 . . . . . . . . . . . . . . . . . . hem Fe

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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