CP2D6_HUMAN_23_497_catalytic

Cytochrome P450 2D6 [Cytochrome P450 family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer
 • A1 (CP2D6_HUMAN):110,112,120,121,208,209,212,213,216,244,247,297,300,301,304,305,308,309,370,374,483,484110,112,120,121,208,209,212,213,216,244,247,297,300,301,304,305,308,309,370,374,483,484
Cofactors (cF):hem
Metals (Me):Fe/Zn

Full PDB list

2f9q,3qm4,3tbg,3tda,4wnt,4wnu,4wnv,4wnw,4xry,4xrz (redundant pocketome entry)

Contact map

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ligand
A1 cF Me
L
1
1
0
F
1
1
2
F
1
2
0
L
1
2
1
L
2
0
8
A
2
0
9
G
2
1
2
L
2
1
3
E
2
1
6
Q
2
4
4
F
2
4
7
I
2
9
7
A
3
0
0
D
3
0
1
S
3
0
4
A
3
0
5
V
3
0
8
T
3
0
9
V
3
7
0
V
3
7
4
F
4
8
3
L
4
8
4
[1]4wnt.a ajn 26 . . . . . . . . . . . . . . . . . . . . . . hem Fe,Zn
[1]4xrz.a si6 24 . . . . . . . . . . . . . . . . . . . . . . hem Fe,Zn
[1]4xry.a si5 25 . . . . . . . . . . . . . . . . . . . . . . hem Fe,Zn
[1]4wnu.a qdn 24 . . . . . . . . . . . . . . . . . . . . . . hem Fe,Zn
[1]3tbg.a rtz 25 . . . . . . . . . . . . . . . . . . . . . . hem Fe,Zn
[1]2f9q.c none . . . . . . . . . . . . . . . . . . . M . . hem Fe
[1]3tda.d pn0 28 . . . . . . . . . . . . . . . . . . . . . . hem Fe
[1]4wnv.a qi9 24 . . . . . . . . . . . . . . . . . . . . . . hem Fe,Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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