CP2C8_HUMAN_20_490

Cytochrome P450 2C8 [Cytochrome P450 family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer
 • A1 (CP2C8_HUMAN):97:100,102,103,106,107,113,114,200,201,204,205,208,209,213,217,236,237,240,241,292,296,297,300,301,362,365:367,476,47797:100,102,103,106,107,113,114,200,201,204,205,208,209,213,217,236,237,240,241,292,296,297,300,301,362,365:367,476,477
Cofactors (cF):hem/plm
Metals (Me):Fe

Full PDB list

1pq2,2nnh,2nni,2nnj,2vn0

Contact map

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ligand
A1 cF Me
R
9
7
G
9
8
N
9
9
S
1
0
0
I
1
0
2
S
1
0
3
I
1
0
6
T
1
0
7
I
1
1
3
S
1
1
4
R
2
0
0
F
2
0
1
N
2
0
4
F
2
0
5
L
2
0
8
N
2
0
9
I
2
1
3
N
2
1
7
N
2
3
6
V
2
3
7
T
2
4
0
R
2
4
1
A
2
9
2
V
2
9
6
A
2
9
7
E
3
0
0
T
3
0
1
V
3
6
2
G
3
6
5
V
3
6
6
P
3
6
7
I
4
7
6
V
4
7
7
[1]2nnj.a 225 25 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . hem,plm Fe
[1]2vn0.a tdz 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . hem,plm Fe
[1]2nni.a mtk 41 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . hem,plm Fe
[1]2nnh.a rea,rea 44 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . hem,plm Fe
[1]1pq2.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . hem,plm Fe

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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