COMT_HUMAN_51_267

Catechol O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer
 • A1 (COMT_HUMAN):88,90,191:195,219,220,223,224,248,249,25188,90,191:195,219,220,223,224,248,249,251
Cofactors (cF):sam
Metals (Me):Mg

Full PDB list

3a7e,3bwm,3bwy,4pyi,4pyj,4pyk,4xuc,4xud,4xue,5lsa (redundant pocketome entry)

Contact map

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ligand
A1 cF Me
W
8
8
M
9
0
D
1
9
1
H
1
9
2
W
1
9
3
K
1
9
4
D
1
9
5
D
2
1
9
N
2
2
0
C
2
2
3
P
2
2
4
L
2
4
8
E
2
4
9
R
2
5
1
[1]4xue.b 43j 21 . . . . . . . . . . . . . . sam Mg
[1]4xuc.a 43g 20 . . . . . . . . . . . . . . sam Mg
[1]4xud.a 43h 23 . . . . . . . . . . . . . . sam Mg
[1]3bwm.a dnc 14 . . . . . . . . . . . . . . sam Mg
[1]4pyk.a none . . . . . . . . . . . . . . Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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