If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

CNO6L_HUMAN_158_555

CCR4-NOT transcription complex subunit 6-like [CCR4/nocturin family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CNO6L_HUMAN):R: Nuclease domain (201, 206, 240, 360, 361, 363, 365, 371, 410, 412:414, 479, 484, 488, 529)201, 206, 240, 360, 361, 363, 365, 371, 410, 412:414, 479, 484, 488, 529

Full PDB list

3ngn, 3ngo, 3ngq, 5dv2, 5dv4

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
Y
2
0
1
L
2
0
6
E
2
4
0
H
3
6
0
M
3
6
1
W
3
6
3
P
3
6
5
K
3
7
1
D
4
1
0
N
4
1
2
L
4
1
4
N
4
7
9
F
4
8
4
I
4
8
8
H
5
2
9
[1]3ngn.a amp23 . . . . . . . . . . . . . . .
[1]3ngo.a AAAA,mg,mg56 . . . . . . . . . . . . . . .
[1]3ngq.a 1ps,mg,mg15 . . . . . . . . . . . . . . .
[1]5dv2.a c5p21 . . . . . . . . . . . . . . .
[1]5dv4.a nmy42 . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
Y
2
0
1
L
2
0
6
E
2
4
0
H
3
6
0
M
3
6
1
W
3
6
3
P
3
6
5
K
3
7
1
D
4
1
0
N
4
1
2
S
4
1
3
L
4
1
4
N
4
7
9
F
4
8
4
I
4
8
8
H
5
2
9
[1]3ngn.a . . . . . . . . . . . . . . . .
[1]3ngo.a . . . . . . . . . . . . . . . .
[1]3ngq.a . . . . . . . . . . . . . . . .
[1]5dv2.a . . . . . . . . . . . . . . . .
[1]5dv4.a . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3ngn.a:amp
3ngo.a:AAAA,mg
3ngq.a:1ps,mg
5dv2.a:c5p
5dv4.a:nmy
[1] 3ngn.a
0.1
0.2 0.1 0 0.6
[1] 3ngo.a 0.1
0.1
0.1 0 0.4
[1] 3ngq.a 0.2 0.1
0.2
0.2 0.6
[1] 5dv2.a 0.2 0.4 0.2
0
0.6
[1] 5dv4.a 0.2 0.5 0.2 0.1
0.4
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3ngn.a
3ngo.a
3ngq.a
5dv2.a
5dv4.a
[1] 3ngn.a
0
.01 .03 .03 .04
[1] 3ngo.a .01
0
.03 .03 .04
[1] 3ngq.a .03 .03
0
.04 .03
[1] 5dv2.a .03 .03 .04
0
.03
[1] 5dv4.a .04 .04 .03 .03
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3ngn.a
3ngo.a
3ngq.a
5dv2.a
5dv4.a
[1] 3ngn.a
0
0.2 0.3 0.2 0.3
[1] 3ngo.a 0.2
0
0.2 0.2 0.2
[1] 3ngq.a 0.3 0.2
0
0.2 0.2
[1] 5dv2.a 0.2 0.2 0.2
0
0.2
[1] 5dv4.a 0.3 0.2 0.2 0.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3ngn.a
3ngo.a
3ngq.a
5dv2.a
5dv4.a
[1] 3ngn.a
0
0.5 0.8 0.8 0.7
[1] 3ngo.a 0.5
0
0.8 0.8 0.7
[1] 3ngq.a 0.8 0.8
0
0.7 0.8
[1] 5dv2.a 0.8 0.8 0.7
0
0.5
[1] 5dv4.a 0.7 0.7 0.8 0.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...