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CLIC2_HUMAN_1_247

Chloride intracellular channel protein 2 [Chloride channel CLIC family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CLIC2_HUMAN):D: GST C-terminal (110, 111, 113, 114, 117, 185, 186, 189)
R: C-terminal (110, 111, 113, 114, 117, 185, 186, 189)
110, 111, 113, 114, 117, 185, 186, 189

Full PDB list

2per, 2r4v, 2r5g (redundant Pocketome entry)

Pocket contact map

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PDB.ch
   
ligand
A1
F
1
1
0
G
1
1
3
C
1
1
4
S
1
8
5
L
1
8
6
K
1
8
9
[1]2per.a mnb13 . . . . . .
[2]2r5g.a none . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
F
1
1
0
D
1
1
1
G
1
1
3
C
1
1
4
F
1
1
7
S
1
8
5
L
1
8
6
K
1
8
9
[1]2per.a . . . . . . . .
[2]2r5g.a . . . * . . . *

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2per.a:mnb
2r5g.a is apo
[1] 2per.a
0.3
-
[2] 2r5g.a 3.2
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2per.a
2r5g.a
[1] 2per.a
0
.36
[2] 2r5g.a .36
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2per.a
2r5g.a
[1] 2per.a
0
1.2
[2] 2r5g.a 1.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2per.a
2r5g.a
[1] 2per.a
0
1.4
[2] 2r5g.a 1.4
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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