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CKI1_SCHPO_1_298

Casein kinase I homolog 1 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CKI1_SCHPO):D: Protein kinase (18:24, 26, 39, 41, 55, 59, 85:90, 94, 133, 135, 136, 138, 153, 154)18:24, 26, 39, 41, 55, 59, 85:90, 94, 133, 135, 136, 138, 153, 154

Full PDB list

1csn, 1eh4, 2csn

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
1
8
G
1
9
E
2
0
G
2
1
S
2
2
I
2
6
A
3
9
K
4
1
E
5
5
Y
5
9
I
8
5
D
8
6
L
8
7
L
8
8
G
8
9
P
9
0
D
9
4
K
1
3
3
D
1
3
5
N
1
3
6
L
1
3
8
V
1
5
3
D
1
5
4
[1]1csn.a atp,mg32 . . . . . . . . . . . . . . . . . . . . . . .
[1]1eh4.b ic123 . . . . . . . . . . . . . . . . . . . . . . .
[1]2csn.a cki18 . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
1
8
G
1
9
E
2
0
G
2
1
S
2
2
F
2
3
G
2
4
I
2
6
A
3
9
K
4
1
E
5
5
Y
5
9
I
8
5
D
8
6
L
8
7
L
8
8
G
8
9
P
9
0
D
9
4
K
1
3
3
D
1
3
5
N
1
3
6
L
1
3
8
V
1
5
3
D
1
5
4
[1]1csn.a . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1eh4.b . . . * * . . . . . . . . . . . . . . . . . . . .
[1]2csn.a . . . . . * . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1csn.a:atp,mg
1eh4.b:ic1
2csn.a:cki
[1] 1csn.a
0
0.4 0.1
[1] 1eh4.b 3.4
0.1
0.2
[1] 2csn.a 2.0 0.5
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1csn.a
1eh4.b
2csn.a
[1] 1csn.a
0
.15 .10
[1] 1eh4.b .15
0
.22
[1] 2csn.a .10 .22
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1csn.a
1eh4.b
2csn.a
[1] 1csn.a
0
1.7 0.8
[1] 1eh4.b 1.7
0
1.8
[1] 2csn.a 0.8 1.8
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1csn.a
1eh4.b
2csn.a
[1] 1csn.a
0
2.2 1.4
[1] 1eh4.b 2.2
0
2.1
[1] 2csn.a 1.4 2.1
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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