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CIPKN_ARATH_22_482

CBL-interacting serine/threonine-protein kinase 23 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CIPKN_ARATH):D: Protein kinase (37, 45, 58, 92, 108:115, 118, 121:123, 161, 171, 172, 175, 185, 187, 189)
R: Activation loop (172, 175, 185, 187, 189)
37, 45, 58, 92, 108:115, 118, 121:123, 161, 171, 172, 175, 185, 187, 189

Full PDB list

4czt, 4czu

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
3
7
V
4
5
A
5
8
I
9
2
L
1
0
8
E
1
0
9
F
1
1
0
V
1
1
1
T
1
1
2
G
1
1
3
G
1
1
4
E
1
1
5
S
1
2
1
L
1
6
1
S
1
7
1
D
1
7
2
L
1
7
5
H
1
8
9
[1]4czt.d cps,cps84 . . . . . . . . . . . . . . . . . .
[1]4czu.d cps42 . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
3
7
V
4
5
A
5
8
I
9
2
L
1
0
8
E
1
0
9
F
1
1
0
V
1
1
1
T
1
1
2
G
1
1
3
G
1
1
4
E
1
1
5
D
1
1
8
S
1
2
1
S
1
2
2
N
1
2
3
L
1
6
1
S
1
7
1
D
1
7
2
L
1
7
5
D
1
8
5
L
1
8
7
H
1
8
9
[1]4czt.d . . . . . . . . . . . . . . . . . . . . . . .
[1]4czu.d . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4czt.d:cps
4czu.d:cps
[1] 4czt.d
0
0.1
[1] 4czu.d 0
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4czt.d
4czu.d
[1] 4czt.d
0
0
[1] 4czu.d 0
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4czt.d
4czu.d
[1] 4czt.d
0
0.5
[1] 4czu.d 0.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4czt.d
4czu.d
[1] 4czt.d
0
1.2
[1] 4czu.d 1.2
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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