CHK1_HUMAN_1_283_allosteric

Serine/threonine-protein kinase Chk1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (CHK1_HUMAN):R: Interaction with CLSPN (93:99,133,173,200,204:208,217)
D: Protein kinase (93:99,133,173,200,204:208,217)
93:99,133,173,200,204:208,217

Full PDB list

1nvs,1zys,2ayp,2br1,2brb,2brg,2brh,2brm,2brn,2bro,2c3k,2cgu,2e9n,2e9o,2e9p,2e9u,2e9v,2gdo,2ghg,2hog,2hxl,2hxq,2hy0,2r0u,2wmx,2xey,2ydi,2ydj,2ydk,2ym4,2ym5,2ym7,2ym8,2ywp,3f9n,3jvr,3jvs,3nlb,3ot3,3ot8,3pa3,3pa4,3pa5,3tkh,3tki,3u9n,4fsm,4fsq,4fsr,4fst,4fsu,4fsy,4ft0,4ft5,4ft7,4fta,4ftc,4fti,4ftj,4ftk,4ftl,4ftm,4ftn,4fto,4ftq,4ftr,4ftt,4ftu,4gh2,4hyh,4hyi,4jik,4qye,4qyf,4qyg,4qyh,4rvk,4rvl,4rvm,5f4n (redundant pocketome entry); 1ia8,1nvq,1nvr,1zlt,2c3j,2c3l,2cgv,2cgw,2cgx,2qhm,2qhn,2wmq,2wmr,2wms,2wmt,2wmu,2wmv,2wmw,2x8d,2x8e,2x8i,2xez,2xf0,2yer,2yex,2ym3,2ym6,4fsn,4fsw,4fsz,4ft3,4ft9,5dls (unprocessed)

Contact map

[download in TSV format]
   
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ligand
A1
F
9
3
D
9
4
R
9
5
I
9
6
E
9
7
P
9
8
D
9
9
P
1
3
3
Y
1
7
3
A
2
0
0
G
2
0
4
E
2
0
5
L
2
0
6
P
2
0
7
W
2
0
8
E
2
1
7
[1]3jvr.a agx 23 . . . . . . . . . . . . . . . .
[1]3jvs.a agy 30 . . . . . . . . . . . . . . . .
[1]3pa4.a none . . . . . . . . . . . . . . . .
[1]3f9n.a 38m 37 . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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