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CFAB_HUMAN_471_764

Complement factor B [Peptidase S1 family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CFAB_HUMAN):D: Peptidase S1 (509, 511, 526, 694:697, 699, 717:723)509, 511, 526, 694:697, 699, 717:723

Full PDB list

1dle, 1rrk, 1rs0, 1rtk, 2ok5, 3hrz, 3hs0 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
E
5
0
9
C
5
1
1
H
5
2
6
T
6
9
4
C
6
9
5
R
6
9
6
G
6
9
7
S
6
9
9
I
7
1
7
S
7
1
8
W
7
1
9
G
7
2
0
V
7
2
1
V
7
2
2
D
7
2
3
[1]1rs0.a dfp10 . . . . . . . * . . . . . . .
[1]1rtk.a gbs12 . . . . . . . * . . . . . . .
[1]3hs0.i none . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
E
5
0
9
C
5
1
1
H
5
2
6
T
6
9
4
C
6
9
5
R
6
9
6
G
6
9
7
S
6
9
9
I
7
1
7
S
7
1
8
W
7
1
9
G
7
2
0
V
7
2
1
V
7
2
2
D
7
2
3
[1]1rs0.a . . . . . . . * . . . . . . .
[1]1rtk.a . . . . . * . * . . . . . . .
[1]3hs0.i . . . . . * . * . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1rs0.a:dfp
1rtk.a:gbs
3hs0.i is apo
[1] 1rs0.a
0.6
0.8 -
[1] 1rtk.a 1.6
0.8
-
[1] 3hs0.i 1.8 1.0
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1rs0.a
1rtk.a
3hs0.i
[1] 1rs0.a
0
.09 .08
[1] 1rtk.a .09
0
.05
[1] 3hs0.i .08 .05
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1rs0.a
1rtk.a
3hs0.i
[1] 1rs0.a
0
0.7 0.8
[1] 1rtk.a 0.7
0
0.6
[1] 3hs0.i 0.8 0.6
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1rs0.a
1rtk.a
3hs0.i
[1] 1rs0.a
0
0.7 0.8
[1] 1rtk.a 0.7
0
1.2
[1] 3hs0.i 0.8 1.2
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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