CDK9_HUMAN_1_331

Cyclin-dependent kinase 9 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (CDK9_HUMAN):D: Protein kinase (23,25:30,32,33,46,48,66,70,79,103:109,149,151,153,154,156,166:168)
R: T-loop (166:168)
23,25:30,32,33,46,48,66,70,79,103:109,149,151,153,154,156,166:168

Full PDB list

3blh,3blq,3blr,3lq5,3mi9,3mia,3my1,3tn8,3tnh,3tni,4bcf,4bcg,4bch,4bci,4bcj,4ec9,4imy,4ogr,4or5 (redundant pocketome entry)

Contact map

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ligand
A1
A
2
3
I
2
5
G
2
6
Q
2
7
G
2
8
T
2
9
F
3
0
E
3
2
V
3
3
A
4
6
K
4
8
E
6
6
L
7
0
V
7
9
F
1
0
3
D
1
0
4
F
1
0
5
C
1
0
6
E
1
0
7
H
1
0
8
D
1
0
9
D
1
4
9
K
1
5
1
A
1
5
3
N
1
5
4
L
1
5
6
A
1
6
6
D
1
6
7
F
1
6
8
[1]3lq5.a slq 32 . . . . - - . . . . . . . . . . . . . . . . . . . . . . .
[1]4bcg.a t3c 30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4bci.a t3e 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4bcf.a t6q 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4bch.a t7z 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4bcj.a t9n 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3blr.a cpb 28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3my1.a rfz 20 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3tn8.a f18 16 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4imy.a amp 23 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3blq.a atp,mg 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3mi9.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3mia.a anp,mg 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]4ogr.a adn 19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4or5.a yt3 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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