CDK12_HUMAN_714_1051

Cyclin-dependent kinase 12 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (CDK12_HUMAN):D: Protein kinase (733,735:737,741,743,754,756,813:819,861,863,864,866,877)
1037,1039,1040
733,735:737,741,743,754,756,813:819,861,863,864,866,877,1037,1039,1040

Full PDB list

4cxa,4nst,4un0,5acb

Contact map

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ligand
A1
I
7
3
3
E
7
3
5
G
7
3
6
T
7
3
7
V
7
4
1
K
7
4
3
A
7
5
4
K
7
5
6
F
8
1
3
E
8
1
4
Y
8
1
5
M
8
1
6
D
8
1
7
H
8
1
8
D
8
1
9
K
8
6
1
S
8
6
3
N
8
6
4
L
8
6
6
D
8
7
7
Q
1
0
3
7
C
1
0
3
9
H
1
0
4
0
[1]5acb.c 5i1 40 . . . . . . . . . . . . . . . . . . . . . * .
[1]4nst.a adp,al,mg,mg 30 . . . . . . . . . . . . . . . . . . . . . . .
[1]4cxa.a anp 31 . . . . . . . . . . . . . . . . . . . . . . .
[1]4un0.c none . . . . . . . . . . . . . . . . . . . . - - -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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