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CDC2H_PLAFK_1_288

Cell division control protein 2 homolog [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CDC2H_PLAFK):D: Protein kinase (10:13, 18, 30, 32, 63, 79:85, 88, 129, 130, 132, 142, 143)10:13, 18, 30, 32, 63, 79:85, 88, 129, 130, 132, 142, 143

Full PDB list

1ob3, 1v0b, 1v0o, 1v0p (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
1
0
G
1
1
E
1
2
G
1
3
V
1
8
A
3
0
K
3
2
V
6
3
F
7
9
E
8
0
H
8
1
L
8
2
D
8
3
Q
8
4
D
8
5
K
8
8
Q
1
2
9
L
1
3
2
A
1
4
2
D
1
4
3
[1]1v0b.a none . . . . . . . . . . . . . . . . . . . .
[1]1v0o.a inr24 . . . . . . . . . . . . . . . . . . . .
[1]1v0p.a pvb30 . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
1
0
G
1
1
E
1
2
G
1
3
V
1
8
A
3
0
K
3
2
V
6
3
F
7
9
E
8
0
H
8
1
L
8
2
D
8
3
Q
8
4
D
8
5
K
8
8
Q
1
2
9
N
1
3
0
L
1
3
2
A
1
4
2
D
1
4
3
[1]1v0b.a . . . . . . . . . . . . . . . * . . . . *
[1]1v0o.a . * . . . . . . . . . . . . . . . . . . .
[1]1v0p.a . . . . . . * . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1v0b.a is apo
1v0o.a:inr
1v0p.a:pvb
[1] 1v0b.a
-
1.2 1.5
[1] 1v0o.a -
0
1.6
[1] 1v0p.a - 1.8
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1v0b.a
1v0o.a
1v0p.a
[1] 1v0b.a
0
.13 .12
[1] 1v0o.a .13
0
.15
[1] 1v0p.a .12 .15
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1v0b.a
1v0o.a
1v0p.a
[1] 1v0b.a
0
1.4 0.5
[1] 1v0o.a 1.4
0
1.5
[1] 1v0p.a 0.5 1.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1v0b.a
1v0o.a
1v0p.a
[1] 1v0b.a
0
2.0 1.3
[1] 1v0o.a 2.0
0
2.1
[1] 1v0p.a 1.3 2.1
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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