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CDC20_HUMAN_162_495

Cell division cycle protein 20 homolog [WD repeat CDC20/Fizzy family]

Composition of the binding site

Protein chains monomer
A1 (CDC20_HUMAN):176, 177, 200, 202, 207, 209, 216176, 177, 200, 202, 207, 209, 216

Full PDB list

4gga, 4ggc, 4ggd, 4n14 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
1
7
6
D
1
7
7
V
2
0
0
L
2
0
2
Y
2
0
7
W
2
0
9
I
2
1
6
[1]4gga.a none . . . . . . .
[1]4ggc.a mrd8 . . . . . . .
[1]4n14.a wr727 . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
1
7
6
D
1
7
7
V
2
0
0
L
2
0
2
Y
2
0
7
W
2
0
9
I
2
1
6
[1]4gga.a . . . . . . .
[1]4ggc.a . . . . . . .
[1]4n14.a . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4gga.a is apo
4ggc.a:mrd
4n14.a:wr7
[1] 4gga.a
-
0 0.1
[1] 4ggc.a -
0
0.1
[1] 4n14.a - 0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4gga.a
4ggc.a
4n14.a
[1] 4gga.a
0
0 .01
[1] 4ggc.a 0
0
.01
[1] 4n14.a .01 .01
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4gga.a
4ggc.a
4n14.a
[1] 4gga.a
0
0.2 0.2
[1] 4ggc.a 0.2
0
0.3
[1] 4n14.a 0.2 0.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4gga.a
4ggc.a
4n14.a
[1] 4gga.a
0
0.5 0.3
[1] 4ggc.a 0.5
0
0.5
[1] 4n14.a 0.3 0.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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