If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

CATG_HUMAN_21_248

Cathepsin G [Peptidase S1 family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CATG_HUMAN):D: Peptidase S1 (48, 49, 64, 105, 108, 176, 196:201, 215:220, 226)48, 49, 64, 105, 108, 176, 196:201, 215:220, 226

Full PDB list

1au8, 1cgh, 1kyn, 1t32

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
C
4
9
H
6
4
I
1
0
5
F
1
7
6
A
1
9
6
F
1
9
7
K
1
9
8
G
1
9
9
D
2
0
0
S
2
0
1
V
2
1
5
S
2
1
6
Y
2
1
7
G
2
1
8
K
2
1
9
S
2
2
0
E
2
2
6
[1]1au8.a 0h831 . . . . . . . . . * . . . . . . .
[1]1cgh.a 1zg33 . . . . . . . . . * . . . . . . .
[1]1kyn.a ktp27 . . . . . . . . . . . . . . . . .
[1]1t32.a ohh49 . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
R
4
8
C
4
9
H
6
4
I
1
0
5
D
1
0
8
F
1
7
6
A
1
9
6
F
1
9
7
K
1
9
8
G
1
9
9
D
2
0
0
S
2
0
1
V
2
1
5
S
2
1
6
Y
2
1
7
G
2
1
8
K
2
1
9
S
2
2
0
E
2
2
6
[1]1au8.a . . . . . . . . * . . * . . . . . . .
[1]1cgh.a . . . . . . . . * . . * . . . . . . .
[1]1kyn.a . . . . . . . . . . . . . . . . . . .
[1]1t32.a . . . . . . . . . . . * . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1au8.a:0h8
1cgh.a:1zg
1kyn.a:ktp
1t32.a:ohh
[1] 1au8.a
0.8
0.4 0.3 1.2
[1] 1cgh.a 0.9
0.6
0.4 1.5
[1] 1kyn.a 0.8 0.7
0
0.9
[1] 1t32.a 1.1 1.0 0.4
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1au8.a
1cgh.a
1kyn.a
1t32.a
[1] 1au8.a
0
.02 .05 .08
[1] 1cgh.a .02
0
.07 .09
[1] 1kyn.a .05 .07
0
.09
[1] 1t32.a .08 .09 .09
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1au8.a
1cgh.a
1kyn.a
1t32.a
[1] 1au8.a
0
0.3 0.6 0.5
[1] 1cgh.a 0.3
0
0.5 0.3
[1] 1kyn.a 0.6 0.5
0
0.5
[1] 1t32.a 0.5 0.3 0.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1au8.a
1cgh.a
1kyn.a
1t32.a
[1] 1au8.a
0
0.4 1.2 1.3
[1] 1cgh.a 0.4
0
0.7 0.8
[1] 1kyn.a 1.2 0.7
0
0.8
[1] 1t32.a 1.3 0.8 0.8
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...