CASP8_HUMAN_219_478

Caspase-8 [Peptidase C14A family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer
 • A1 (CASP8_HUMAN):254,257,258,260,261,316:318,324,358:360,365,410:416,419,420,455,457,458254,257,258,260,261,316:318,324,358:360,365,410:416,419,420,455,457,458

Full PDB list

1f9e,1i4e,1qdu,1qtn,2c2z,2fun,2y1l,3h11,3kjn,3kjq,4jj7,4prz,4ps1

Contact map

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ligand
A1
L
2
5
4
I
2
5
7
R
2
5
8
R
2
6
0
N
2
6
1
S
3
1
6
H
3
1
7
G
3
1
8
Y
3
2
4
Q
3
5
8
A
3
5
9
C
3
6
0
Y
3
6
5
V
4
1
0
S
4
1
1
Y
4
1
2
R
4
1
3
N
4
1
4
P
4
1
5
A
4
1
6
T
4
1
9
W
4
2
0
D
4
5
5
K
4
5
7
N
4
5
8
[1]2c2z.a phqLETmx5 56 . . . . . . . . . . . * . - - - - - - - - - - - -
[1]3kjq.a b94 29 . . . . . . . . . . . * . - - - - - - - - - - - -
[1]3kjn.a b93 43 . . . . . . . . . . . * . - - - - - - - - - - - -
[1]1f9e.c phqDEVasa 42 . . . . . . . . . . . * . . . . . . . . . . . . .
[1]1i4e.b CV-YSDQMD 64 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1qdu.a phqEVD0qe 27 . . . . . . . . . . . * . . . . . . . . . . . . .
[1]1qtn.a aceIETasj 35 . . . . . . . . . . . * . - - - - - - - - - - - -
[1]2fun.d CV-DYSDQMD 72 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2y1l.a IETD 32 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3h11.b AIETasa 37 . . . . . . . . . . . . . . . . . . . . . . - - -
[1]4jj7.a ace.1mhDb3l.hlx.1u8 49 . . . . . . . . . . . * . . . . . . . . . . . . .
[1]4prz.a aceLET1u8 36 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ps1.c balLQhyp.1u8 39 . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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