If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

CAH7_HUMAN_2_263

Carbonic anhydrase 7 [Alpha-carbonic anhydrase family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (CAH7_HUMAN):D: Alpha-carbonic anhydrase (94, 96, 98, 121, 123, 133, 137, 200:204, 211)
R: Substrate binding (201, 202)
94, 96, 98, 121, 123, 133, 137, 200:204, 211
Metals (Me):Zn

Full PDB list

3mdz, 3ml5

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 Me
Q
9
4
H
9
6
H
9
8
H
1
2
1
V
1
2
3
F
1
3
3
A
1
3
7
L
2
0
0
T
2
0
1
T
2
0
2
P
2
0
3
P
2
0
4
W
2
1
1
[1]3mdz.a ezl16 . . . . . . . . . . . . . Zn
[1]3ml5.a azm13 . . . . . . . . . . . . . Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 Me
Q
9
4
H
9
6
H
9
8
H
1
2
1
V
1
2
3
F
1
3
3
A
1
3
7
L
2
0
0
T
2
0
1
T
2
0
2
P
2
0
3
P
2
0
4
W
2
1
1
[1]3mdz.a . . . . . . . . . . . . . Zn
[1]3ml5.a . . . . . . . . . . . . . Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3mdz.a:ezl
3ml5.a:azm
[1] 3mdz.a
0
0
[1] 3ml5.a 0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3mdz.a
3ml5.a
[1] 3mdz.a
0
0
[1] 3ml5.a 0
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3mdz.a
3ml5.a
[1] 3mdz.a
0
0.7
[1] 3ml5.a 0.7
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3mdz.a
3ml5.a
[1] 3mdz.a
0
0.8
[1] 3ml5.a 0.8
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...