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C1S_HUMAN_432_688

Complement C1s subcomponent [Peptidase S1 family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (C1S_HUMAN):D: Peptidase S1 (511, 528, 615, 670, 671, 673, 674)511, 528, 615, 670, 671, 673, 674

Full PDB list

1elv, 4j1y, 5ubm (redundant Pocketome entry)

Pocket contact map

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PDB.ch
   
ligand
A1
H
5
1
1
N
5
2
8
N
6
1
5
N
6
7
0
Y
6
7
1
D
6
7
3
W
6
7
4
[1]1elv.a nes14 . . . . . . .
[1]4j1y.a none . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
H
5
1
1
N
5
2
8
N
6
1
5
N
6
7
0
Y
6
7
1
D
6
7
3
W
6
7
4
[1]1elv.a . . . . . . .
[1]4j1y.a . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1elv.a:nes
4j1y.a is apo
[1] 1elv.a
0
-
[1] 4j1y.a 0
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1elv.a
4j1y.a
[1] 1elv.a
0
0
[1] 4j1y.a 0
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1elv.a
4j1y.a
[1] 1elv.a
0
0.2
[1] 4j1y.a 0.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1elv.a
4j1y.a
[1] 1elv.a
0
0.9
[1] 4j1y.a 0.9
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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