BTK_HUMAN_2_170

Tyrosine-protein kinase BTK [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (BTK_HUMAN):D: PH (12,14:18,21,22,24,26,28,39,53)
R: Inositol-(1,3,4,5)-tetrakisphosphate 1- binding (12,14:18,21,22,24)
12,14:18,21,22,24,26,28,39,53

Full PDB list

1b55,1btk,1bwn,2z0p,4y93,4y94 (redundant pocketome entry)

Contact map

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ligand
A1
K
1
2
S
1
4
Q
1
5
Q
1
6
K
1
7
K
1
8
S
2
1
P
2
2
N
2
4
K
2
6
R
2
8
Y
3
9
K
5
3
[1]4y93.a none . . - - - - - - . . . . .
[1]1btk.b none . . . . . . . . . . C . .
[1]1bwn.a 4ip 28 . . . . . . . . . . . . .
[1]2z0p.a 4pt 28 . . . . . . . . . . . . .
[1]4y94.c ihp 36 . . . - - - - - . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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